Acquired uniparental disomy of chromosome 9p in hematologic malignancies.


Acquired uniparental disomy (aUPD) is a common and recurrent molecular event in human cancers that leads to homozygosity for tumor suppressor genes as well as oncogenes, while retaining the diploid chromosomal complement. Because of the lack of copy number change, aUPD is undetectable by comparative genome hybridization, so the magnitude of this genetic… (More)
DOI: 10.1016/j.exphem.2015.11.005


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