Acquired skeletal muscle metabolic myopathy in atherosclerotic peripheral arterial disease.

@article{Brass2000AcquiredSM,
  title={Acquired skeletal muscle metabolic myopathy in atherosclerotic peripheral arterial disease.},
  author={Eric P. Brass and William R Hiatt},
  journal={Vascular medicine},
  year={2000},
  volume={5 1},
  pages={
          55-9
        }
}
Peripheral arterial disease (PAD) is associated with an increased risk of overall cardiovascular mortality, and substantial morbidity resulting from claudication. While the initial disease process is clearly the result of atherosclerosis in the arterial circulation of the limb, altered hemodynamics do not completely explain the pathophysiology of claudication. Work from several laboratories has demonstrated secondary changes in the skeletal muscle of patients with PAD which are consistent with… CONTINUE READING
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