Acquired resistance to Fasciola hepatica in cattle using a purified adult worm antigen.

Calves were immunized twice in 4 weeks with a Fasciola/Schistosoma cross-reactive, cross-protective defined immunity antigen (denoted FhSmIII(M)) isolated from F. hepatica adult worm extracts by antibody affinity chromatography and challenged 7 weeks later with F. hepatica metacercariae. Flukes were recovered at 16 weeks of infection at which time the… CONTINUE READING