Acquired neuronal channelopathies in HIV-associated dementia

  title={Acquired neuronal channelopathies in HIV-associated dementia},
  author={Benjamin B. Gelman and Vicki M. Soukup and Kimberly W Schuenke and Michael J. Keherly and Christopher J Lahart},
  journal={Journal of Neuroimmunology},
A gene expression profile of the human brain cortex was performed in people with HIV-1-associated dementia (HAD) using Affymetrix HG-U133 chips. Messenger RNA transcripts in middle frontal gyrus from subjects with HAD or milder neurocognitive dysfunction were compared to HIV-negative people. The analysis focused on ionic conductance carriers that control membrane excitation. Overexpressed ionic channel genes in brain cortex of subjects with dementia included (1) a calcium-driven K+ channel that… CONTINUE READING


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