Acquired nephrogenic diabetes insipidus.

  title={Acquired nephrogenic diabetes insipidus.},
  author={Apurv Khanna},
  journal={Seminars in nephrology},
  volume={26 3},
Nephrogenic diabetes insipidus (NDI) is defined as the inability of the kidney to concentrate urine owing to the insensitivity of the distal nephron to the antidiuretic hormone, arginine vasopressin. NDI can be either a congenital or an acquired disorder. Acquired NDI most commonly is secondary to drugs such as lithium or metabolic disturbances, such as hypokalemia and hypercalcemia. Disturbance of the aquaporin-2 shuttle is the underlying molecular basis of acquired NDI. NDI is diagnosed with… CONTINUE READING


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