Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

@article{Honjo2001AcquiredMI,
  title={Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.},
  author={Y Honjo and Christine A Hrycyna and Q W Yan and Wilma Y Medina-P{\'e}rez and Robert W. Robey and Arnold W. J. M. van de Laar and T Litman and M Dean and S E Bates},
  journal={Cancer research},
  year={2001},
  volume={61 18},
  pages={6635-9}
}
A disparity was noted in the transport of rhodamine 123 among nine MXR/BCRP/ABCP-overexpressing cells studied; all demonstrated mitoxantrone transport, whereas only two effluxed rhodamine 123. When the MXR/BCRP/ABCP gene was sequenced in the cell lines studied, differences were noted at amino acid 482, predicted to be at the start of the third transmembrane domain. Sequencing genomic DNA revealed wild-type MXR/BCRP/ABCP to have an arginine at position 482. Cells having a threonine or glycine at… CONTINUE READING
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