Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

@article{Baxter2005AcquiredMO,
  title={Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders},
  author={E. Baxter and L. Scott and P. Campbell and C. East and A. Green},
  journal={The Lancet},
  year={2005},
  volume={365},
  pages={1054-1061}
}
BACKGROUND Human myeloproliferative disorders form a range of clonal haematological malignant diseases, the main members of which are polycythaemia vera, essential thrombocythaemia, and idiopathic myelofibrosis. [...] Key MethodMETHODS We obtained DNA samples from patients with polycythaemia vera, essential thrombocythaemia, or idiopathic myelofibrosis. The coding exons of JAK2 were bidirectionally sequenced from peripheral-blood granulocytes, T cells, or both.Expand
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