Acquired interferon gamma responsiveness during Caco-2 cell differentiation: effects on iNOS gene expression.

@article{Chvez1999AcquiredIG,
  title={Acquired interferon gamma responsiveness during Caco-2 cell differentiation: effects on iNOS gene expression.},
  author={Alejandro Mun{\~o}z Ch{\'a}vez and Merribeth J. Morin and Naoki Unno and Mitchell P. Fink and Richard Aaron Hodin},
  journal={Gut},
  year={1999},
  volume={44 5},
  pages={
          659-65
        }
}
BACKGROUND Impairment of intestinal barrier function occurs under a variety of inflammatory conditions and is mediated at least in part by interferon gamma (IFN-gamma) induced nitric oxide (NO) production. Previous in vivo studies have shown that systemic lipopolysaccharide treatment caused an induction of the rat inducible nitric oxide synthase (iNOS) mRNA primarily in villus cells, rather than in undifferentiated crypt cells. AIMS To examine iNOS induction by IFN-gamma in vitro as a… CONTINUE READING
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