Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor.

@article{Pallais2004AcquiredHH,
  title={Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor.},
  author={J. C. Pallais and O. Kifor and Yi-Bin Chen and D. Slovik and E. Brown},
  journal={The New England journal of medicine},
  year={2004},
  volume={351 4},
  pages={
          362-9
        }
}
A complex homeostatic system involving the interplay of bone, the kidneys, and the intestines maintains extracellular calcium levels within a relatively narrow range. This article describes a patient with autoimmune hyperparathyroidism and hypocalciuric hypercalcemia caused by IgG4 autoantibodies directed against the calcium-sensing receptor. The patient's hypercalcemia and elevated parathyroid hormone levels responded to the administration of glucocorticoids. 
Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium‐sensing receptor
Activating antibodies directed at the extracellular calcium‐sensing receptor (CaSR) have been described in autoimmune hypoparathyroidism in the setting of isolated hypoparathyroidism or autoimmuneExpand
Anti-parathyroid and anti-calcium sensing receptor antibodies in autoimmune hypoparathyroidism.
  • E. Brown
  • Medicine
  • Endocrinology and metabolism clinics of North America
  • 2009
TLDR
A few hypercalcemic patients with autoimmune hypocalciuric hypercalcemia owing to anti-CaSR antibodies that inhibit receptor activation have now been identified, suggesting that new approaches to treatment, such as CaSR antagonists or agonists (calcilytics/calcimimetics), may be worthwhile. Expand
Autoimmune hypocalciuric hypercalcemia unresponsive to glucocorticoid therapy in a patient with blocking autoantibodies against the calcium-sensing receptor.
TLDR
The anti-CaSR antibody-mediated inhibition of CaSR-stimulated ERK1/2 activity, but not of inositol-1-phosphate accumulation, suggests that ERK 1/2 may mediate, at least in part, the regulation of PTH secretion and urinary calcium excretion by the CaSR. Expand
Dissimilar PTH, Gastrin, and Calcitonin Responses to Oral Calcium and Peptones in Hypocalciuric Hypercalcemia, Primary Hyperparathyroidism, and Normal Subjects: A Useful Tool for Differential Diagnosis
TLDR
Diverse hormonal responses to oral calcium and peptones in hypocalciuric hypercalcemia, mild primary hyperparathyroidism, and normal controls are observed that may help in the differential diagnosis of these conditions. Expand
Acquired hypocalciuric hypercalcemia in a patient with CKD.
TLDR
Consideration is given of the presence of inhibitory autoantibodies directed at the CaSR in patients with hypercalcemic hyperparathyroidism and unexplained hypocalciuria or with confounding conditions affecting interpretation of urinary calcium measurement. Expand
Parathyroid and autoimmunity.
  • C. Betterle
  • Medicine, Biology
  • Annales d'endocrinologie
  • 2006
TLDR
The article takes into consideration the different clinical forms, genetic patterns, histopathology, animal models, cellular immunity, circulating autoantibodies, target autoantigens, clinical manifestations, laboratory diagnosis and therapy and data on 71 Italian patients with chronic hypoparathyroidism. Expand
Hyperparathyroidism in a patient with autoimmune polyglandular syndrome.
TLDR
Anti-parathyroid autoantibodies were detected by indirect immunofluorescence on parathyroid adenomas, andAutoantibody against a peptide of the extracellular domain of the calcium-sensing receptor were detect by immunoblotting. Expand
Autoimmune hypercalcemia due to autoantibodies against the calcium-sensing receptor.
TLDR
AHH is to be suspected in patients with an acquired biochemical pattern of PTH-dependant hypocalciuric hypercalcemia, especially in those with other concomitant autoimmune diseases, including Hashimoto's disease and thyroid autoimmunity. Expand
An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations
TLDR
Observations indicate that a calcium-stimulated CaSR primed by a specific autoantibody adopts a unique conformation that activates Gq but not Gi, and speculate that physiological modulators may exist that enable an agonist to specifically activate only one signaling pathway via a GPCR that activates multiple signaling pathways. Expand
Activating autoantibodies against the calcium-sensing receptor detected in two patients with autoimmune polyendocrine syndrome type 1.
TLDR
Although the majority of APS1 patients do not have CaSR-stimulating antibodies, there may be a small but substantial minority of patients in whom the hypoparathyroid state is the result of functional suppression of the parathyroid glands rather than their irreversible destruction. Expand
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