Acquired homozygosity (isodisomy) of chromosome 3 during clonal evolution of a uveal melanoma: association with morphologic heterogeneity.

@article{White1996AcquiredH,
  title={Acquired homozygosity (isodisomy) of chromosome 3 during clonal evolution of a uveal melanoma: association with morphologic heterogeneity.},
  author={Valerie Ann White and Brian Mcneil and Luc Thiberville and Douglas E. Horsman},
  journal={Genes, chromosomes & cancer},
  year={1996},
  volume={15 2},
  pages={138-43}
}
Cytogenetic investigation of untreated uveal melanoma has shown that the most frequent abnormality is monosomy 3, which occurs in approximately 60% of cases. One of our cases showed distinct pigmented and nonpigmented areas at gross dissection; representative tissue was collected separately from each area, cultured, and harvested using standard cytogenetic… CONTINUE READING

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