Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes

@article{Khan2015AcquiredGA,
  title={Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes},
  author={F. H. Khan and V. Pandian and S. Ramraj and M. Natarajan and S. Aravindan and T. Herman and N. Aravindan},
  journal={BMC Cancer},
  year={2015},
  volume={15}
}
BackgroundDetermining the driving factors and molecular flow-through that define the switch from favorable to aggressive high-risk disease is critical to the betterment of neuroblastoma cure.MethodsIn this study, we examined the cytogenetic and tumorigenic physiognomies of distinct population of metastatic site- derived aggressive cells (MSDACs) from high-risk tumors, and showed the influence of acquired genetic rearrangements on poor patient outcomes.ResultsKaryotyping in SH-SY5Y and MSDACs… Expand
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