Acquired expression of p27 is a favorable prognostic indicator in patients with hepatocellular carcinoma.

@article{Fiorentino2000AcquiredEO,
  title={Acquired expression of p27 is a favorable prognostic indicator in patients with hepatocellular carcinoma.},
  author={Michelangelo Fiorentino and Annalisa Altimari and Antonietta D'errico and Barry Cukor and Chiara Barozzi and Massimo Loda and Walter Franco Grigioni},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 10},
  pages={3966-72}
}
The p27 cyclin-dependent kinase inhibitor is a negative regulator of cell-cycle progression. In many human epithelial malignancies, decreased expression of p27 correlates with high grade, early recurrence, and poor prognosis. To evaluate the prognostic significance of p27 in hepatocellular carcinoma (HCC), we studied 54 HCCs along with corresponding nontumoral tissue. Immunohistochemistry (IHC) and Western blot (WB) analysis before and after immunoprecipitation with Cdk2 were performed on… CONTINUE READING
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