Acquired estrogen independence and antiestrogen resistance in breast cancer: estrogen receptor driven phenotypes?

@article{Clarke1996AcquiredEI,
  title={Acquired estrogen independence and antiestrogen resistance in breast cancer: estrogen receptor driven phenotypes?},
  author={Robert Clarke and Nits Br{\"u}nner},
  journal={Trends in endocrinology and metabolism: TEM},
  year={1996},
  volume={7 8},
  pages={291-301}
}
Endocrine-responsive breast tumors appear to follow a predictable pattern of progression from estrogen dependence to estrogen independence, ultimately leading to a phenotype characterized by crossresistance among all endocrine therapies. Cells acquiring a multihormone-resistant phenotype, however, frequently retain expression of the cellular receptors for estrogen (ER) and progesterone (PgR). The proliferation of some of these tumors may be driven by a ligand-independent activation of the… CONTINUE READING
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