Acquired erythroenzymopathy in a monozygotic twin with acute myeloid leukemia.


The specific activity of several red cell enzymes was studied in a pair of monozygotic twins, one of whom presented acute myeloblastic leukemia. When the intrapair variation of these twins was compared with that of a series of nine normal twins, a significant decrease in phosphoglycerate kinase, diphosphoglycerate mutase, pyruvate kinase, lactic dehydrogenase, adenylate kinase and glucose-6-phosphate dehydrogenase activities and an increase in 6-phosphogluconate dehydrogenase activity were demonstrable for the leukemic twin. The heat stability of the leukemic proband's pyruvate kinase at pH 8.0 and 56 degrees C was less than that of the normal twin, suggesting an acquired qualitative disorder.

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@article{Barretto1986AcquiredEI, title={Acquired erythroenzymopathy in a monozygotic twin with acute myeloid leukemia.}, author={Orlando C{\'e}sar de Oliveira Pereira Barretto and Kimiyo Nonoyama and Gloria M . D . D . Colletto}, journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas}, year={1986}, volume={19 1}, pages={63-7} }