Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD.

@article{Dransfield2013AcquiredCF,
  title={Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD.},
  author={Mark Thomas Dransfield and Andrew M. Wilhelm and Brian J. Flanagan and Clifford A Courville and Sherry L Tidwell and S Vamsee Raju and Amit Gaggar and Chad Steele and Li ping Tang and Bo Liu and Steven M Rowe},
  journal={Chest},
  year={2013},
  volume={144 2},
  pages={
          498-506
        }
}
BACKGROUND Cigarette smoke and smoking-induced inflammation decrease cystic fibrosis transmembrane conductance regulator (CFTR) activity and mucociliary transport in the nasal airway and cultured bronchial epithelial cells. This raises the possibility that lower airway CFTR dysfunction may contribute to the pathophysiology of COPD. We compared lower airway CFTR activity in current and former smokers with COPD, current smokers without COPD, and lifelong nonsmokers to examine the relationships… CONTINUE READING
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