Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.

@article{Parker1991AcquiredCR,
  title={Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.},
  author={Robert J. Parker and A. Eastman and F W Bostick-Bruton and Eddie B. Reed},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={87 3},
  pages={772-7}
}
Studies were undertaken to investigate acquired resistance to cisplatin in human ovarian cancer cells. The cell lines A2780 and A2780/CP70 were studied to assess their respective characteristics of drug accumulation and efflux, cytosolic inactivation of drug, and DNA repair. All experiments were performed using 1-h drug exposures. The A2780/CP70 cell line was 13-fold more resistant to cisplatin than A2780 cells. When studied at their respective IC50 doses, drug accumulation rates were similar… CONTINUE READING
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An evaluation of platinum - DNA adduct levels relative to known prognostic variables in a cohort of ovarian cancer patients

  • F. Bostick-Bruton, J. Vionnet, V. A. Bohr
  • 1990

Cisplatin and platinum analogs

  • B. A. Chabner, D. Scudiero
  • Cancer Chemotherapy : Principles and Practice .
  • 1990

Mecha - nisms of resistance to platinum drugs

  • M. J. Egorin, A. M. J. Fichingter-Schepman, E. Reed
  • 1988

Quantitation of platinum - DNA binding in human tissues following therapeutic levels of drug exposure

  • M. C. McGahan, K. Tyczkowska
  • Atomic Spectroscopy .
  • 1988

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