Acquired aplastic anemia.

@article{Young2002AcquiredAA,
  title={Acquired aplastic anemia.},
  author={Neal S. Young},
  journal={Annals of internal medicine},
  year={2002},
  volume={136 7},
  pages={534-46}
}
In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endogenous antigens generated by genetically altered bone marrow cells. In patients with post-hepatitis… CONTINUE READING
115 Citations
62 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 115 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Immune modulation of myelodysplasia: rationale and therapy

  • NS Young, AJ Barrett
  • 2002
2 Excerpts

Treatment of bone marrow failure of myelodysplastic syndrome with antithymocyte globulin

  • J Molldrem, M Rivera, E Bahceci, C Dunbar, J Liu, Y Saunthararajah
  • Ann Intern Med. [In press] Update Acquired…
  • 2002
1 Excerpt

A randomized trial comparing antithymocyte globulin and cyclosporin to cyclophosphamide and cyclosporin for initial treatment in severe aplastic anemia: results of long-term follow-up [Abstract

  • JF Tisdale, JP Maciejewski, O Nunez, SJ Rosenfeld, NS. Young
  • Blood. 2001;98(Part 1):223a
  • 2001
1 Excerpt

Similar Papers

Loading similar papers…