Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs.

@article{hov2002AcquiredAS,
  title={Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs.},
  author={Blanka Ř{\'i}hov{\'a} and Jiř{\'i} Strohalm and Kateřina Kub{\'a}{\vc}kov{\'a} and Mark{\'e}ta Jel{\'i}nkov{\'a} and Ondřej Hovorka and Marek Kov{\'a}ř and Dana Plocov{\'a} and Milada {\vS}{\'i}rov{\'a} and Marek St'astn{\'y} and Lad'ka Rozprimov{\'a} and Karel Ulbrich},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2002},
  volume={78 1-3},
  pages={97-114}
}
We present data providing new evidence that poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA)-bound drugs, unlike free drugs, have both cytostatic and immunomobilizing activity (CIA). Immediately after injection, due to the high level of the drug, the main activity of the polymeric conjugate is cytotoxic and cytostatic. Later on, long-term circulating PHPMA-bound drug, at concentrations lower than its minimal inhibitory levels, mobilizes the defense mechanisms of the host. Cytotoxic and… CONTINUE READING
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