AcpA is a Francisella acid phosphatase that affects intramacrophage survival and virulence.

@article{Mohapatra2007AcpAIA,
  title={AcpA is a Francisella acid phosphatase that affects intramacrophage survival and virulence.},
  author={Nrusingh Prasad Mohapatra and Ashwin Balagopal and Shilpa Soni and Larry S. Schlesinger and John S Gunn},
  journal={Infection and immunity},
  year={2007},
  volume={75 1},
  pages={
          390-6
        }
}
AcpA of Francisella spp. is a respiratory-burst-inhibiting acid phosphatase that also exhibits phospholipase C activity. To better understand the molecular basis of AcpA in virulence, a deletion of acpA was constructed in Francisella novicida. The phosphatase and lipase activities were reduced 10-fold and 8-fold, respectively, in the acpA mutant compared to the wild type and were found mostly associated with the outer membrane. The acpA mutant was more susceptible to intracellular killing than… CONTINUE READING

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