Acoustic overstimulation increases outer hair cell Ca2+ concentrations and causes dynamic contractions of the hearing organ.

@article{Fridberger1998AcousticOI,
  title={Acoustic overstimulation increases outer hair cell Ca2+ concentrations and causes dynamic contractions of the hearing organ.},
  author={Anders Fridberger and Ake Flock and Mats Ulfendahl and Britta Flock},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 12},
  pages={7127-32}
}
The dynamic responses of the hearing organ to acoustic overstimulation were investigated using the guinea pig isolated temporal bone preparation. The organ was loaded with the fluorescent Ca2+ indicator Fluo-3, and the cochlear electric responses to low-level tones were recorded through a microelectrode in the scala media. After overstimulation, the amplitude of the cochlear potentials decreased significantly. In some cases, rapid recovery was seen with the potentials returning to their initial… CONTINUE READING

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