Acoustic droplet vaporization and propulsion of perfluorocarbon-loaded microbullets for targeted tissue penetration and deformation.

@article{Kagan2012AcousticDV,
  title={Acoustic droplet vaporization and propulsion of perfluorocarbon-loaded microbullets for targeted tissue penetration and deformation.},
  author={Daniel Kagan and Michael J. Benchimol and Jonathan C. Claussen and Erdembileg Chuluun-Erdene and Sadik C. Esener and Joseph Wang},
  journal={Angewandte Chemie},
  year={2012},
  volume={51 30},
  pages={
          7519-22
        }
}
Acoustic droplet vaporization of perfluorocarbon-loaded microbullets triggered by an ultrasound pulse provides the necessary force to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery. 
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250 Citations
Highly Influential Citations
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Background Citations
38
Methods Citations
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250 Citations

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References

SHOWING 1-10 OF 41 REFERENCES

Acoustic droplet vaporization for therapeutic and diagnostic applications.

Investigation of vaporized submicron perfluorocarbon droplets as an ultrasound contrast agent.

Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent

TLDR
Two methods to lower the ADV threshold at a lower 1.44 MHz were explored, finding the threshold was found to be 5.5-5.9 MPa for short microsecond pulses and decreased for millisecond pulses.

Bubble evolution in acoustic droplet vaporization at physiological temperature via ultra-high speed imaging

Acoustic droplet vaporization in a rigid tube at body temperature was investigated experimentally using an ultra-high speed camera. This study was motivated by gas embolotherapy, a developmental…

Controlled propulsion of artificial magnetic nanostructured propellers.

TLDR
The construction and operation of chiral colloidal propellers that can be navigated in water with micrometer-level precision using homogeneous magnetic fields are reported.

Microbots swimming in the flowing streams of microfluidic channels.

TLDR
The motion of self-propelled catalytic Ti/Fe/Pt rolled-up microtubes (microbots) in the microchannels of a microfluidics system are described and the transport of multiple spherical microparticles into desired locations is achieved.

Drug loaded microbubble design for ultrasound triggered delivery

TLDR
Why it is attractive to load the microbubbles with drugs is described and recent attempts made in the design of drug loaded microbubble are discussed.

Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons.

Physical principles of microbubble ultrasound contrast agents.

Microbubbles in ultrasound-triggered drug and gene delivery.