Acoustic Startle-Evoked Potentials in the Rat Amygdala: Effect of Kindling

  title={Acoustic Startle-Evoked Potentials in the Rat Amygdala: Effect of Kindling},
  author={Ulrich Ebert and Michael Koch},
  journal={Physiology \& Behavior},
  • U. Ebert, M. Koch
  • Published 1 September 1997
  • Biology, Psychology
  • Physiology & Behavior
Ventral pallidum mediates amygdala-evoked deficits in prepulse inhibition.
It is suggested that BLA inactivation disrupts PPI through disinhibition of VP, and the effect on PPI of bilateral and unilateral inactivation of BLA is evaluated by microinfusion of the GABA-A receptor agonist, muscimol.
The neurobiology of startle
  • M. Koch
  • Biology, Psychology
    Progress in Neurobiology
  • 1999
Establishment and evaluation of rat epilepsy model by basolateral amygdala kindling
The rat epileptic model by BLA kindling is successfully established and may be a good tool for investigating the epilepsy mechanism, prevention and treatment.
Repeated elicitation of the acoustic startle reflex leads to sensitisation in subsequent avoidance behaviour and induces fear conditioning
Evidence is presented that repeated elicitation of the acoustic startle reflex leads to rapid and pronounced sensitisation of sustained spatial avoidance behaviour in grey seals and indicates that repeated startling by anthropogenic noise sources might have severe effects on long-term behaviour.
Trace Eyeblink Conditioning in Mice Is Dependent upon the Dorsal Medial Prefrontal Cortex, Cerebellum, and Amygdala: Behavioral Characterization and Functional Circuitry1,2,3
It is shown here that mice can acquire trace conditioned responses (tCRs) devoid of startle while head-restrained and permitted to freely run on a wheel, the first report of trace eyeblink conditioning in mice in which tCRs were driven by the cerebellum and required a localized region of mPFC for acquisition.
Serotonin transporter gene variation impacts innate fear processing: acoustic startle response and emotional startle
The results provide first evidence that the startle response is sensitive to genetic variation in the serotonin pathway, and may provide a valuable endophenotype of fear processing and underlying serotonergic influences.
Stathmin, a gene regulating neural plasticity, affects fear and anxiety processing in humans
  • B. Brocke, K. Lesch, C. Kirschbaum
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2010
It is found that STMN1 genotype interacting with individuals' gender significantly impacts fear and anxiety responses as measured with the startle and cortisol stress response, and it is concluded that stathmin genotype has functional relevance for the acquisition and expression of basic fear and Anxiety responses also in humans.


A primary acoustic startle circuit: lesion and stimulation studies
The data suggest that a primary acoustic startle circuit in the rat consists of auditory nerve, ventral cochlear nucleus, nuclei of the lateral lemniscus, nucleus reticularis pontis caudalis, spinal interneuron, lower motor neuron, and muscles.
Single-unit activity in the lateral nucleus of the amygdala and overlying areas of the striatum in freely behaving rats: rates, discharge patterns, and responses to acoustic stimuli.
Together the findings from awake and anesthetized rats provide the most precise information about sensory processing in amygdala neurons available to date.
Modification of seizure activity by electrical stimulation. II. Motor seizure.
  • R. Racine
  • Biology, Psychology
    Electroencephalography and clinical neurophysiology
  • 1972
Unit responses evoked in the amygdala and striatum by electrical stimulation of the medial geniculate body
Findings are consistent with anatomical tracing studies showing that AL, AST, and CPU receive direct projections from the MGB and related acoustic processing areas of the thalamus but that ACE, ABL, and ABM do not.