Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride.

@article{Matsunaga2011AcotiamideH,
  title={Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride.},
  author={Yugo Matsunaga and Takao Tanaka and Koji Yoshinaga and Shigeru Ueki and Yuko Hori and Runa Eta and Yoshihiro Kawabata and Kazuyoshi Yoshii and Kenji Yoshida and Toshihiro Matsumura and Shigeru Furuta and Mineo Takei and Jan Tack and Zen Itoh},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={336 3},
  pages={791-800}
}
Acotiamide hydrochloride (acotiamide; N-[2-[bis(1-methylethyl) amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl) amino] thiazole-4-carboxamide monohydrochloride trihydrate, Z-338) has been reported to improve meal-related symptoms of functional dyspepsia in clinical studies. Here, we examined the gastroprokinetic effects of acotiamide and its antiacetylcholinesterase activity as a possible mechanism of action in conscious dogs. Acotiamide increased postprandial gastric motor activity in… CONTINUE READING
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The role of the cholinergic nervous system in the gastrointestinal responses to motilin in vivo

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