Aconite poisoning

  title={Aconite poisoning},
  author={Thomas Yan Keung Chan},
  journal={Clinical Toxicology},
  pages={279 - 285}
  • T. Y. Chan
  • Published 1 April 2009
  • Medicine, Biology
  • Clinical Toxicology
Introduction. Aconitine and related alkaloids found in the Aconitum species are highly toxic cardiotoxins and neurotoxins. The wild plant (especially the roots and root tubers) is extremely toxic. Severe aconite poisoning can occur after accidental ingestion of the wild plant or consumption of an herbal decoction made from aconite roots. In traditional Chinese medicine, aconite roots are used only after processing to reduce the toxic alkaloid content. Soaking and boiling during processing or… 
Reversible intraventricular conduction defect in aconite poisoning: A Case report
In traditional Chinese medicine, aconite roots are used only after processing to reduce the toxic alkaloid content, and soaking and boiling during processing will hydrolyze aconite alkaloids into less toxic and non-toxic derivatives.
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The public should be warned of the risk of severe poisoning related to the culinary and traditional medicinal uses of aconite roots and the risks posed by these “food supplements”.
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The advances of AC metabolism are reviewed and the latest mechanistic findings of cardiac efficacy and toxicity of this aconite alkaloid or its metabolites are focused on to provide new insight into the paradoxical nature of this ancient poison.
Comparison of a specific HPLC determination of toxic aconite alkaloids in processed Radix aconiti with a titration method of total alkaloids
The HPLC method developed provides a quick and reliable assessment of toxicity and should be considered as a purity test in pharmacopoeia monographs.
A case report of cardiotoxicity due to homeopathic drug overdose
Aconite is one of the most toxic plants. Aconitine and related alkaloids found in the Aconitum species are highly toxic cardiotoxins and neurotoxins. Severe aconite poisoning can occur after
Causes and prevention of herb-induced aconite poisonings in Asia
  • T. Chan
  • Medicine, Chemistry
    Human & experimental toxicology
  • 2011
The recent reports from Hong Kong, Taiwan, China and Korea were reviewed to determine the causes and prospects for prevention of herb-induced aconite poisonings. The contributory factors included
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Yunaconitne, a highly toxic aconitum alkaloid, was thus identified in human urine for the first time and is an important diagnostic aid for acute poisoning by aconites of an unclear origin.
Severe Acute Poisoning with Homemade Aconitum napellus Capsules: Toxicokinetic and Clinical Data
The authors stress that clinicians must be aware of possible occurrence of acute poisoning with Aconitum napellus in European countries and in the United States as herbal medicine is becoming increasingly popular.
Aconitine poisoning due to Chinese herbal medicines: a review.
Clinicians should be alerted to the potential toxicity of "chuanwu" and "caowu", the root of A kusnezoffii, which contain the highly toxic C19 diterpenoid alkaloids of aconitine, mesaconitine and hypaconitines.
Distribution of Aconitum alkaloids in body fluids and tissues in a suicidal case of aconite ingestion.
Findings show that Aconitum alkaloids were found in the liver and kidneys in much higher concentrations than in serum and suggest that they were eliminated not only via urine but also in feces.
Incidence of Herb-Induced Aconitine Poisoning in Hong Kong
It is suggested that publicity measures to promote awareness, among the herbalists and the public, may reduce the incidence of poisoning due to toxic herbs such as aconite roots in the New Territories East.
A case of aconitine poisoning with analysis of aconitine alkaloids by GC/SIM.
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Arrow poisons in China. Part II. Aconitum--botany, chemistry, and pharmacology.
  • N. Bisset
  • Chemistry
    Journal of ethnopharmacology
  • 1981
Quantitative analysis of Aconitum alkaloids in the urine and serum of a male attempting suicide by oral intake of aconite extract.
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Determination of Aconitum alkaloids in the tubers of Aconitum japonicum using gas chromatography/selected ion monitoring.
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