Acne Pathogenesis: History of Concepts

  title={Acne Pathogenesis: History of Concepts},
  author={G{\'e}rard Tilles},
  pages={1 - 46}
  • G. Tilles
  • Published 13 September 2014
  • Medicine
  • Dermatology
From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as… 

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The aim of this study was to review the literature regarding the new concepts on the pathogenesis of acne to find out whether modifications in the sebum composition lead to a greater proliferation and differentiation of keratinocytes that obstruct the follicular ostium and favor the formation of comedones.

Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes

The treatment of acne with phages may be important in order to reduce the overuse of antibiotics, which are currently the main acne treatment, however, more detailed studies are first needed to understand phage functioning in the skin microbiome and the possibility to use phages to combat P. acnes.

Cutibacterium acnes: Much ado about maybe nothing much

If and how C. acnes (still) fits into the developing view on acne is explored, and the implications for therapy in the light of antibiotic resistance and the need for more targeted therapies are discussed.

High Body Mass Index is a Risk Factor for Acne Severity in Adolescents: A Preliminary Report.

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Dosages of androgenic hormones in adolescent patients with severe acne.

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The prevalence of heterozygous CYP21A2 deficiency in patients with idiopathic acne, hirsutism, or both

The prevalence of heterozygotic CYP21A2 mutation detected in patients with acne, hirsutism, or both was significantly higher than in the general population and whether the heterozygous mutation of CYP 21A2 is the cause of clinical symptoms needs further assessment.

Acne treatment efficacy of intense pulsed light photodynamic therapy with topical licochalcone A, l‐carnitine, and decanediol: A spilt‐face, double‐blind, randomized controlled trial

Depending on disease severity, standard acne treatments can vary from topical to systemic therapy. However, poor compliance caused by adverse events and antibiotic resistance is a major cause of

Daily Routine in Cosmetic Dermatology

  • M. IssaB. Tamura
  • Medicine
    Clinical Approaches and Procedures in Cosmetic Dermatology
  • 2017
This first chapter is the first and essential step for the construction of your knowledge on cosmetic procedures, and it is essential to have full knowledge of the histology, physiology, and topographic particularities of the skin.




It is a curious phenomenon that lesions of acne vulgaris develop on the forehead, face, interscapular and sternal regions, shoulders, chest, dorsum and trunk, but never on the scalp, and the utmost importance should be attached to the peculiar histologic structure of sebaceous glands and hairs in various parts of the body.

The pathogenesis and treatment of acne.

  • P. Pochi
  • Medicine, Biology
    Annual review of medicine
  • 1990
Therapy involves treatments that modify these pathogenic factors and includes drugs with antikeratinizing, antibacterial, and antiseborrheic actions.


Further work on the association between acne and seborrhea is dependent on more accurate knowledge of the latter condition, particularly the change in the nature and amount of sebum.

The role of inflammation in the pathogenesis of acne and acne scarring.

Acne: inflammation.

The pathologic dynamics of acne vulgaris

The purpose of this exhibit is to display the pathologic events in acne vulgaris, where the lesions of acne occur in special follicles, the sebaceous follicle, which are found in great abundance on the cheek and forehead.

Effect of tetracycline on the composition of sebum in acne vulgaris.

ACNE vulgaris is a common inflammatory disorder of the skin involving pilosebaceous structures; its pathogenesis is imperfectly understood. Earliest lesions demonstrate a partial rupture of the


The subject of this paper has been chosen not only with the purpose of reviewing some of the knowledge of the causes of acne but more particularly to inquire how far the authors' methods of treatment coincide with that knowledge.

What is the pathogenesis of acne?

Pathogenesis and Pathogenesis Related Treatment of Acne

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