Aclidinium bromide for the treatment of chronic obstructive pulmonary disease

@article{Cazzola2013AclidiniumBF,
  title={Aclidinium bromide for the treatment of chronic obstructive pulmonary disease},
  author={Mario Cazzola and Clive P Page and Maria Gabriella Matera},
  journal={Expert Opinion on Pharmacotherapy},
  year={2013},
  volume={14},
  pages={1205 - 1214}
}
Introduction: Although there are some challenges with current therapies, the growing evidence that tiotropium bromide is important in the maintenance treatment of chronic obstructive pulmonary disease (COPD) has led to enthusiastic investigation in search of novel muscarinic antagonists which share some of the beneficial characteristics of tiotropium and perhaps improve upon less desirable ones. Areas covered: Aclidinium bromide is a new muscarinic antagonist that has been developed to relieve… 
7 Citations
Muscarinic Receptor Antagonists.
TLDR
Treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients and further beneficial effects of SAMAs and LAMAs are seen when added to existing treatments, including LABAs, inhaled corticosteroids and phosphodiesterase 4 inhibitors.
Chronic obstructive pulmonary disease b2-Agonists Antimuscarinic agents Methylxanthines Choice of bronchodilators Emerging bronchodilators
TLDR
It is likely that an approach using muscarinic antagonist b2-agonist (MABA) molecules will provide the best opportunity to develop combinations that combine corticosteroids with 2 bronchodilator activities, and thus potentially achieve better efficacy than is apparent with the current combination products that dominate the treatment of COPD.
Bronchodilators: current and future.
TLDR
The muscarinic β2-agonist molecules approach likely provides the best opportunity to develop combinations that combine corticosteroids with dual-bronchodilator activities, and thus potentially achieve better efficacy than is apparent with the current combination products that dominate the treatment of COPD.
AUTHOR PROOF COPY Not for publication
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It is documented that ACLI/FORM, a twice- daily fixed-dose combination, produces a greater degree of bronchodilation than ACLI or FORM monotherapy alone and is safe and well tolerated.
High altitude pulmonary edema among “Amarnath Yatris”
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Altitude sickness is common among Amaranath Yatris from the plains and appropriate educational strategies should be invoked for prevention and prompt treatment.
Forme cristalline et amorphe de chlorure d'aclidinium et procédé de préparation correspondant
L'invention concerne de nouvelles formes de chlorure d'aclidinium de formule I. Le procede de preparation de chlorure d'aclidinium cristallin consiste a mettre en reaction l'ester de quinuciidinyle
Respiratory Disorders, 4. Inhalants for Obstructive Airway Diseases (R03)

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