Aclidinium Bromide Twice Daily for the Treatment of Chronic Obstructive Pulmonary Disease: A Review

@article{Jones2013AclidiniumBT,
  title={Aclidinium Bromide Twice Daily for the Treatment of Chronic Obstructive Pulmonary Disease: A Review},
  author={Paul W Jones},
  journal={Advances in Therapy},
  year={2013},
  volume={30},
  pages={354-368}
}
  • Paul W Jones
  • Published 2 April 2013
  • Medicine
  • Advances in Therapy
The inhaled, long-acting muscarinic antagonist, aclidinium bromide, was indicated in July 2012 in Europe and the USA for the maintenance of bronchodilator treatment to relieve symptoms of chronic obstructive pulmonary disease (COPD) in adults. Although initially investigated as a once-daily agent, a lower than expected improvement in trough forced expiratory volume over 1 s prompted re-evaluation as a twice-daily (b.i.d.) regimen. The dose approved for use in Europe, 400 μg b.i.d., achieved… 
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Efficacy and Safety of an Aclidinium Bromide Treatment for 12 Weeks or Longer in Patients with Moderate-To-Severe COPD: A Meta-Analysis
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ATOMIC ABSORPTION SPECTROMETRIC DETERMINATION OF ACLIDINIUM BROMIDE USING AMMONIUM REINECKATE
Atomic absorption spectrometric method has been developed for determination of aclidinium bromide in its pure and pharmaceutical dosage form. The method was based on the ability of aclidinium bromide
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Цель обзора: рассмотреть этиологию, клинические последствия, средства профилактики и лечения обострений хронической обструктивной болезни легких (ХОБЛ). Основные положения. Как правило, ХОБЛ
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References

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TLDR
Aclidinium is effective and well tolerated in patients with moderate to severe chronic obstructive pulmonary disease and time to first moderate or severe COPD exacerbation is significantly delayed in ACCLAIM/COPD II.
Improvement in symptoms and rescue medication use with aclidinium bromide in patients with chronic obstructive pulmonary disease: Results from ATTAIN
TLDR
Aclidinium 200 μg and 400 μg twice-daily provided statistically significant and clinically meaningful improvements in COPD symptoms in patients with moderate to severe COPD.
S51 Efficacy of Aclidinium Bromide Compared with Tiotropium and Placebo in Patients with Moderate to Severe COPD: A Phase IIIb Study
TLDR
Aclidinium 400 µg BID provided significant 24-hour bronchodilatory symptom control and daily symptom improvement throughout the study, with numerically greater improvement in morning and night-time symptoms among aclid inium-treated patients.
P189 Reduced COPD Exacerbations Associated with Aclidinium Bromide Versus Placebo: A Pooled Analysis of Phase III Data
TLDR
A pooled analysis provides evidence to support a reduction in moderate or severe COPD exacerbations with aclidinium 200 µg and 400 µg BID compared with placebo.
Long-term efficacy of twice-daily aclidinium bromide in COPD patients: A one-year study
TLDR
Treatment with aclidinium 200 µg or 400 µg BID results in benefits in lung function and health status in COPD patients over 1 year, and both treatment groups showed clinically significant improvements in SGRQ Total score and improvements in EuroQoL parameters.
Safety and pharmacokinetics of multiple doses of aclidinium bromide administered twice daily in healthy volunteers.
TLDR
Aclidinium bromide exhibited time-independent PK following dosing to steady state, indicating that similar concentration versus time profiles will occur after repeated administration at the same dose and frequency.
Efficacy and safety of twice-daily aclidinium bromide in COPD patients: the ATTAIN study
TLDR
Twice-daily aclidinium significantly improved bronchodilation, health status and dyspnoea, and was well tolerated in patients with COPD.
Efficacy of aclidinium bromide 400 μg twice daily compared with placebo and tiotropium in patients with moderate to severe COPD.
TLDR
In patients with COPD, aclidinium 400 μg bid compared with placebo provided clinically meaningful improvements in 24-h bronchodilation that generally were comparable to tiotropium 18 μg daily but with significant differences in favor of aclIDinium observed in the average nighttime period.
Efficacy and Safety of a 12-week Treatment with Twice-daily Aclidinium Bromide in COPD Patients (ACCORD COPD I)
TLDR
Treatment of moderate-to-severe COPD patients with twice-daily aclidinium 200 μg and 400 μg was associated with significant improvements in bronchodilation, health status, and COPD symptoms and both doses were well tolerated and had safety profiles similar to placebo.
Twice-daily aclidinium bromide in COPD patients: A pooled analysis of lung function in the ACCORD-COPD I and ATTAIN trials
TLDR
Both doses of aclidinium produced significant improvements in lung function in COPD patients, with the 400 µg dose being consistently more effective.
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