Acitretin and skin cancer in kidney transplanted patients. Clinical and histological evaluation and immunohistochemical analysis of lymphocytes, natural killer cells and Langerhans’ cells in sun exposed and sun protected skin

  title={Acitretin and skin cancer in kidney transplanted patients. Clinical and histological evaluation and immunohistochemical analysis of lymphocytes, natural killer cells and Langerhans’ cells in sun exposed and sun protected skin},
  author={Renata V Carneiro and Mirian Nacagami Sotto and Luiz S{\'e}rgio Azevedo and Luiz Estevan Ianhez and Evandro A. Rivitti},
  journal={Clinical Transplantation},
Abstract:  Background:  Renal transplanted recipients have an increased incidence of actinic keratosis and skin cancer. 
About the cutaneous targets of bexarotene in CTCL patients
About the cutaneous targets of bexarotene in CTCL patients and their potential applications in wound care and oncology is described.
Clinicopathologic analysis of malignant or premalignant cutaneous neoplasms in Japanese kidney transplant recipients
It is suggested that, among Japanese recipients of kidney transplant, MPCNs in sun-exposed skin areas may be associated with immunosuppression and ultraviolet exposure.
Reducing non‐melanoma skin cancer risk in renal transplant recipients
The clinical and financial burden of transplant‐associated skin cancers, carcinogenic mechanisms in association with immunosuppression, importance of skin cancer awareness campaign and integrated transplant skin clinic, and the potential role of chemoprotective agents are highlighted.
Aggressive Cutaneous Squamous Cell Carcinoma Associated with Prolonged Voriconazole Therapy in a Renal Transplant Patient
An alternative antifungal prophylaxis regimen (for instance with posaconazole) should be considered when evaluating patients for solid organ transplantation who are at high risk for the development of cutaneous malignancies.
Management of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients
The challenge of managing posttransplant CSCC in the OTR population is addressed with a summary of the current therapeutic strategies in this patient cohort and the management of metastatic CSCC remains challenging.
Solar keratosis: Epidemiology, pathogenesis, presentation and treatment
Traditional therapies, such as liquid nitrogen cryotherapy, are still popular, but newer choices are now providing further options with similar efficacy and superior adverse effect profiles, albeit at a higher cost.
Retinoids for Chemoprophylaxis of Nonmelanoma Skin Cancer
The authors have indicated no significant interest with commercial supporters and the results will not be biased towards any particular religion or ethnic group.
An investigation of Langerhans' cell function in aged skin
Characterising the mechanistic basis for the reduced frequency and restricted mobility of epidermal LCs in the skin of the elderly demonstrated that changes in LC function in the elderly may not be associated with changes in systemic DC biology and cutaneous microenvironment changes are likely to be more relevant.


A study was performed to evaluate the possible effect of topical tretinoin on the number of Langerhans’cells in human beings.
Skin cancer in organ transplant recipients: Epidemiology, pathogenesis, and management.
  • D. Berg, C. Otley
  • Medicine
    Journal of the American Academy of Dermatology
  • 2002
The epidemiology and clinical presentation of skin cancer during posttransplantation immunosuppression is described, pathogenic cofactors are discussed, and the optimal management for mild and severe skin cancer in transplant recipients is reviewed.
Use of acitretin for the skin complications in renal transplant recipients.
Most patients treated with acitretin experienced subjective improvement and actinic keratoses and warts improved or disappeared and its effect on the skin malignancy rate was variable.
Topical tretinoin replenishes CD1a‐positive epidermal Langerhans cells in chronically photodamaged human skin
This work asked whether topical tretinoin would reverse Langerhans cell depletion in chronically photodamaged skin and found that it would.
CD4 lymphocytopenia as a risk factor for skin cancers in renal transplant recipients.
CD4 cell depletion is associated with skin cancer in long-term renal transplant recipients, and total lymphocyte and CD8 and CD19 cell counts were similar between the two groups.
Skin cancers in transplant patients.
  • B. Dréno, E. Mansat, B. Legoux, P. Litoux
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 1998
The high frequency of these skin tumors in transplant patients and their potential for progression require preventive and therapeutic measures: regular examination of the skin, strict advice about protection from sun exposure, excision of any suspect lesion, and treatment of warts that might be conducive to the development of skin cancers.
Lymphocyte subsets and Langerhans cells in sun-protected and sun-exposed skin of immunosuppressed renal allograft recipients.
Skin cancer chemoprophylaxis in renal transplant recipients: 5 years of experience using low‐dose acitretin
  • Mckenna, Murphy
  • Medicine, Biology
    The British journal of dermatology
  • 1999
The introduction of low‐dose acitretin proved to be a useful strategy in the long‐term reduction of skin cancer in renal transplant recipients with multiple skin cancers and extensive epidermal dysplasia.
Treatment of cutaneous neoplasia with etretinate in renal transplant recipients.
In-vivo measures of the cutaneous cell-mediated immune response were unaltered, but cell kinetic studies demonstrated an increase in proliferative activity in sun-exposed skin during treatment, suggesting that the anti-tumour effect of etretinate is not due to a cytostatic action, and does not require an intact immune system.
Prevention of skin cancer and reduction of keratotic skin lesions during acitretin therapy in renal transplant recipients: a double-blind, placebo-controlled study.
Acitretin 30 mg/d over 6 months had significantly more effect than placebo in the prevention of squamous cell carcinomas and reduced the occurrence of keratotic skin lesions in a group of renal transplant recipients with severe lesions.