Acinetobacter baumannii outer membrane protein a induces dendritic cell death through mitochondrial targeting

  title={Acinetobacter baumannii outer membrane protein a induces dendritic cell death through mitochondrial targeting},
  author={J. Lee and C. Choi and J. Kim},
  journal={The Journal of Microbiology},
  • J. Lee, C. Choi, +1 author J. Lee
  • Published 2010
  • Biology, Medicine
  • The Journal of Microbiology
  • Acinetobacter baumannii outer membrane protein A (AbOmpA) is a potential virulence factor that induces epithelial cell death, but its pathologic effects on the immune system have yet to be determined. The present study investigated the pathologic events occurring in dendritic cells (DCs) exposed to a cytotoxic concentration of AbOmpA. AbOmpA induced early-onset apoptosis and delayed-onset necrosis in DCs. AbOmpA targeted the mitochondria and induced the production of reactive oxygen species… CONTINUE READING
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