Acinetobacter baumannii outer membrane protein a induces dendritic cell death through mitochondrial targeting

@article{Lee2010AcinetobacterBO,
  title={Acinetobacter baumannii outer membrane protein a induces dendritic cell death through mitochondrial targeting},
  author={Jun Sik Lee and Chul Hee Choi and Jung Wook Kim and Je Chul Lee},
  journal={The Journal of Microbiology},
  year={2010},
  volume={48},
  pages={387-392}
}
Acinetobacter baumannii outer membrane protein A (AbOmpA) is a potential virulence factor that induces epithelial cell death, but its pathologic effects on the immune system have yet to be determined. The present study investigated the pathologic events occurring in dendritic cells (DCs) exposed to a cytotoxic concentration of AbOmpA. AbOmpA induced early-onset apoptosis and delayed-onset necrosis in DCs. AbOmpA targeted the mitochondria and induced the production of reactive oxygen species… 
Stenotrophomonas maltophilia outer membrane protein A induces epithelial cell apoptosis via mitochondrial pathways
TLDR
The data suggested that rOmpA induced epithelial cells apoptosis via mi-tochondrial pathways, which is similar to previous studies on OmpA.
The Acinetobacter baumannii Omp33-36 Porin Is a Virulence Factor That Induces Apoptosis and Modulates Autophagy in Human Cells
TLDR
The study found that Omp33-36 plays an important role in the pathogenesis of A. baumannii infections and was used as a virulence factor in macrophages and a mouse model of systemic infection.
Thioredoxin-mediated alteration of protein content and cytotoxicity of Acinetobacter baumannii outer membrane vesicles
TLDR
Investigating whether OMVs can be modulated by TrxA found that up-regulated and unique ΔtrxA OMV proteins consisted of many membrane bound proteins involved in small molecule transport as well as proteolytic activity, which may contribute to the increased cytotoxicity observed in this study.
Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection
TLDR
This review summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A.baumannII infection, and emphasized the feasibility of using AbOmp a as a potential therapeutic target.
Acinetobacter baumannii Virulence Attributes: The Roles of Outer Membrane Protein A, Acinetobactin-mediated Iron Acquisition Functions, and Blue Light Sensing Protein A
TLDR
It was proven that the death of these cells is a result of an induction of apoptosis and secreted proteins in addition to OmpA are implicated in that process, and it was also proven that purified cell-free siderophore is capable of inducing an apoptotic response.
Outer membrane Protein A plays a role in pathogenesis of Acinetobacter nosocomialis
TLDR
This study is the first report that links OmpA to A. nosocomialis pathogenesis, and highlights ompA as a putative target to develop anti-virulence agents or vaccines against A. NosocomialIS infection.
Outer membrane protein A and OprF: versatile roles in Gram‐negative bacterial infections
TLDR
How various regions present in the extracellular loops of OmpA contribute to the pathogenesis of neonatal meningitis induced by E. coli K1 and to many other functions is described.
...
...

References

SHOWING 1-10 OF 21 REFERENCES
Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity
TLDR
The microinjection of rAbOmpA into the nucleus of Xenopus laevis embryos fails to develop normal embryogenesis, thus leading to embryonic death, and a novel pathogenic mechanism of A. baumannii regarding the nuclear targeting of the bacterial structural protein AbOmp a is proposed.
Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells
TLDR
It is demonstrated that Omp38 may act as a potential virulence factor to induce apoptosis of epithelial cells in the early stage of A. baumannii infection.
Acinetobacter baumannii invades epithelial cells and outer membrane protein A mediates interactions with epithelial cells
TLDR
The role of A. baumannii outer membrane protein A (AbOmpA) in interactions with epithelial cells plays a major role in the interactions in the early stage of bacterial infection.
Proteome analysis of outer membrane vesicles from a clinical Acinetobacter baumannii isolate.
TLDR
The results suggest that OMVs from A. baumannii are an important vehicle designed to deliver effector molecules to host cells, and several putative virulence-associated proteins were also identified.
Enteropathogenic Escherichia coli EspF is targeted to mitochondria and is required to initiate the mitochondrial death pathway
TLDR
Assessment of mitochondrial membrane potential in infected epithelial cells indicated that EspF plays a role in the mitochondrial membrane permeabilization induced by EPEC infection, and findings indicate a role for EspF in initiating the mitochondrial death pathway.
Targeting of the pro‐apoptotic VDAC‐like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells
TLDR
It is shown that porin is selectively and efficiently transported to mitochondria of infected cells and suggested that the Neisseria porin can, like its eukaryotic homologue, function at the mitochondrial checkpoint to mediate apoptosis.
Serum resistance of Acinetobacter baumannii through the binding of factor H to outer membrane proteins.
TLDR
Results indicate that A. baumannii evades complement attack through the acquisition of factor H to their surface, suggesting that AbOmpA was an important complement regulator-acquiring surface protein.
Apoptosis Induced by Pseudomonas aeruginosa in Antigen Presenting Cells Is Diminished by Genetic Modification with CD40 Ligand
TLDR
It is demonstrated that DC and AM are susceptible to apoptosis induced by PA and that this response can be partially reversed by genetic modification with CD40L, a CD4+ T cell molecule that plays a central role in activating antigen presenting cells.
...
...