Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases

  title={Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases},
  author={Frank Thomas Bergmann and Sebastian Aulmann and Bence Sipos and Matthias Kloor and Anja von Heydebreck and Johannes Schweipert and Andreas Harjung and Philipp F J Mayer and W. Hartwig and Gerhard Moldenhauer and David R. Capper and Gerhard Dyckhoff and Kolja Freier and Esther Herpel and Anja Schleider and Peter Schirmacher and Gunhild Mechtersheimer and Guenter Kloeppel and Hendrik Blaeker},
  journal={Virchows Archiv},
Pancreatic acinar cell carcinomas (PACs) are rare but are distinct aggressive neoplasms that phenotypically differ from pancreatic ductal adenocarcinomas (PDACs) and pancreatic neuroendocrine neoplasms (PNENs). Despite recent work on the genetic changes of PACs, their molecular pathogenesis is still poorly understood. In this study, we focus on a comparative genomic hybridization analysis. Based on frequent chromosomal imbalances, the involvement of DCC and c-MYC in the pathogenesis of PACs is… CONTINUE READING
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