Acidosis mediates the upregulation of UT-A protein in livers from uremic rats.

@article{Klein2002AcidosisMT,
  title={Acidosis mediates the upregulation of UT-A protein in livers from uremic rats.},
  author={Janet D Klein and Patricia Rouillard and Brian R. Roberts and Jeff M Sands},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 3},
  pages={581-7}
}
Liver expresses a 49-kD UT-A protein whose abundance is increased by uremia. Chronic renal failure causes acidosis; therefore, the role of acidosis in increasing UT-A abundance was tested. Rats underwent 5/6 nephrectomy, and half were given bicarbonate mixed in their food. Bicarbonate administration significantly increased blood pH. Compared with sham-operated rats, UT-A protein abundance was significantly increased by 50% in livers from uremic, acidotic rats; bicarbonate administration… CONTINUE READING
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