Acidosis inhibits osteoblastic and stimulates osteoclastic activity in vitro.

@article{Krieger1992AcidosisIO,
  title={Acidosis inhibits osteoblastic and stimulates osteoclastic activity in vitro.},
  author={Nancy S. Krieger and Nicole Sessler and David A. Bushinsky},
  journal={The American journal of physiology},
  year={1992},
  volume={262 3 Pt 2},
  pages={F442-8}
}
Metabolic acidosis induces net calcium flux (JCa) from cultured neonatal mouse calvariae through physicochemical and cell-mediated mechanisms. To determine the role of osteoblasts in acid-induced JCa, collagen synthesis and alkaline phosphatase activity were assessed in calvariae incubated in reduced pH and bicarbonate medium, a model of metabolic acidosis (Met), and compared with controls (Ctl). Collagen synthesis fell from 30.5 +/- 1.1 in Ctl to 25.1 +/- 0.4% with Met, and alkaline… CONTINUE READING