Acidosis improves uptake of antigens and MHC class I-restricted presentation by dendritic cells.

@article{Vermeulen2004AcidosisIU,
  title={Acidosis improves uptake of antigens and MHC class I-restricted presentation by dendritic cells.},
  author={M{\'o}nica Vermeulen and Mirta Nilda Giordano and Anal{\'i}a S Trevani and Christine Sedlik and Romina Gamberale and Paula X Fern{\'a}ndez-Calotti and Gabriela Ver{\'o}nica Salamone and Silvina Raiden and J. L. Rey Sanjurjo and Jorge Ra{\'u}l Geffner},
  journal={Journal of immunology},
  year={2004},
  volume={172 5},
  pages={3196-204}
}
It is widely appreciated that inflammatory responses in peripheral tissues are usually associated to the development of acidic microenvironments. Despite this, there are few studies aimed to analyze the effect of extracellular pH on immune cell functions. We analyzed the impact of acidosis on the behavior of dendritic cells (DCs) derived from murine bone marrow. We found that extracellular acidosis (pH 6.5) markedly stimulated the uptake of FITC-OVA, FITC-dextran, and HRP by DCs. In fact, to… CONTINUE READING