Acidosis causes endoplasmic reticulum stress and caspase-12-mediated astrocyte death.

@article{Aoyama2005AcidosisCE,
  title={Acidosis causes endoplasmic reticulum stress and caspase-12-mediated astrocyte death.},
  author={Koji Aoyama and David M. Burns and Sang Won Suh and Philippe Garnier and Yasuhiko Matsumori and Hiroaki Shiina and Raymond A Swanson},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2005},
  volume={25 3},
  pages={358-70}
}
Endoplasmic reticulum (ER) stress leads to activation of caspase-12, which in turn can lead to activation of caspase-3 and cell death. Here we report that transient acidosis induces ER stress and caspase-12-mediated cell death in mouse astrocytes. After a 3-hour incubation at pH 6.0, astrocytes exhibited delayed cell death associated with nuclear condensation and fragmentation. Cell death was reduced by the protein synthesis inhibitor cycloheximide, further suggesting an active cell death… CONTINUE READING