Acidosis Differentially Modulates Inactivation in NaV1.2, NaV1.4, and NaV1.5 Channels

  title={Acidosis Differentially Modulates Inactivation in NaV1.2, NaV1.4, and NaV1.5 Channels},
  author={Yury Y. Vilin and Colin H Peters and Peter C Ruben},
  booktitle={Front. Pharmacol.},
Na(V) channels play a crucial role in neuronal and muscle excitability. Using whole-cell recordings we studied effects of low extracellular pH on the biophysical properties of Na(V)1.2, Na(V)1.4, and Na(V)1.5, expressed in cultured mammalian cells. Low pH produced different effects on different channel subtypes. Whereas Na(V)1.4 exhibited very low sensitivity to acidosis, primarily limited to partial block of macroscopic currents, the effects of low pH on gating in Na(V)1.2 and Na(V)1.5 were… CONTINUE READING
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3:109. doi: 10.3389/fphar.2012.00109 This article was submitted to Frontiers in Pharmacology of Ion Channels and Channelopathies, a specialty

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