Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis

@inproceedings{Dong2013AcidosisAO,
  title={Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis},
  author={Lixue Dong and Zhigang Li and Nancy R. Leffler and Adam S. Asch and Jen-Tsan Chi and Li V Yang},
  booktitle={PloS one},
  year={2013}
}
Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic organs, sickle cell disease, and many other pathological conditions due to hypoxia, glycolytic cell metabolism and deficient blood perfusion. However, the molecular mechanisms by which cells sense and respond to the acidic microenvironment are not well understood. GPR4 is a proton-sensing receptor expressed in endothelial cells and other cell types. The receptor is fully activated by acidic extracellular… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Why do cancers have high aerobic glycolysis?

Nature Reviews Cancer • 2004
View 4 Excerpts
Highly Influenced

Acidosis-related damage.

Advances in neurology • 1996
View 5 Excerpts
Highly Influenced

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