Acidosis, not azotemia, stimulates branched-chain, amino acid catabolism in uremic rats.

@article{Hara1987AcidosisNA,
  title={Acidosis, not azotemia, stimulates branched-chain, amino acid catabolism in uremic rats.},
  author={Yoshiki Hara and Ron Crews May and Ralph A. Kelly and William E. Mitch},
  journal={Kidney international},
  year={1987},
  volume={32 6},
  pages={808-14}
}
To investigate branched-chain, amino acid metabolism (BCAA) in muscle in chronic renal failure (CRF), we studied rats with moderately severe uremia (PUN 110 approximately mg/dl) and spontaneous metabolic acidosis (bicarbonate, 19 +/- 1 mEq/liter). Plasma BCAA levels in CRF compared to pair-fed control rats were approximately 15% lower and muscle valine was 93 microM lower (P less than 0.05). BCAA metabolism was measured in incubated epitrochlearis muscles using L-[1-14C]valine or L-[1-14C… CONTINUE READING

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