Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity.

@article{Huang2013AcidocalcisomesOT,
  title={Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity.},
  author={Guozhong Huang and Paula J. Bartlett and A. P. Thomas and Silvia N. J. Moreno and Roberto Docampo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 5},
  pages={1887-92}
}
Acidocalcisomes are acidic calcium stores rich in polyphosphate and found in a diverse range of organisms. The mechanism of Ca(2+) release from these organelles was unknown. Here we present evidence that Trypanosoma brucei acidocalcisomes possess an inositol 1,4,5-trisphosphate receptor (TbIP(3)R) for Ca(2+) release. Localization studies in cell lines expressing TbIP(3)R in its endogenous locus fused to an epitope tag revealed its partial colocalization with the vacuolar proton pyrophosphatase… CONTINUE READING