Acidity generated by the tumor microenvironment drives local invasion.

  title={Acidity generated by the tumor microenvironment drives local invasion.},
  author={Veronica C. Estrella and Tingan Chen and Mark Lloyd and Jonathan Wojtkowiak and Heather H. Cornnell and Arig Ibrahim-Hashim and Kate Bailey and Yoganand Balagurunathan and Jennifer M. Rothberg and Bonnie F Sloane and Joseph Johnson and Robert A. Gatenby and Robert J. Gillies},
  journal={Cancer research},
  volume={73 5},
The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive growth and metastasis. The hypothesis that acid mediates invasion proposes that H(+) diffuses from the proximal tumor microenvironment into adjacent normal tissues where it causes tissue remodeling that permits local invasion. In the current work, tumor invasion and peritumoral pH were monitored over time using intravital microscopy. In… CONTINUE READING