Acidified bile acids increase hTERT expression via c-myc activation in human gastric cancer cells.

@article{Wang2015AcidifiedBA,
  title={Acidified bile acids increase hTERT expression via c-myc activation in human gastric cancer cells.},
  author={Xiaolong Wang and Peihua Zhou and Xuejun Sun and Jianbao Zheng and Guangbing Wei and Li Zhang and Hui Wang and Jianfeng Yao and Shaoying Lu and Pengbo Jia},
  journal={Oncology reports},
  year={2015},
  volume={33 6},
  pages={3038-44}
}
Human telomerase reverse transcriptase (hTERT) is upregulated in most cancer cell types as well in immortalized cells. The underlying mechanism for such upregulation, however, remains largely unknown. We report here that bile acids under acidified media increase hTERT expression via c-myc activation in primary human gastric cancer cell lines. Human gastric… CONTINUE READING