Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption.

@article{Karsdal2005AcidificationOT,
  title={Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption.},
  author={Morten Asser Karsdal and Kim Henriksen and Mette G S{\o}rensen and Jes Tougaard Gram and Sophie Schaller and M H Dziegiel and Anne-Marie Heegaard and Palle Christophersen and T John Martin and Chris Christiansen and Jens Bollerslev},
  journal={The American journal of pathology},
  year={2005},
  volume={166 2},
  pages={
          467-76
        }
}
Patients with defective osteoclastic acidification have increased numbers of osteoclasts, with decreased resorption, but bone formation that remains unchanged. We demonstrate that osteoclast survival is increased when acidification is impaired, and that impairment of acidification results in inhibition of bone resorption without inhibition of bone formation. We investigated the role of acidification in human osteoclastic resorption and life span in vitro using inhibitors of chloride channels… CONTINUE READING

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