Acidification of the intimal fluid: the perfect storm for atherogenesis.

  title={Acidification of the intimal fluid: the perfect storm for atherogenesis.},
  author={Katariina {\"O}{\"o}rni and Kristiina Rajam{\"a}ki and Su Duy Nguyen and Katariina L{\"a}hdesm{\"a}ki and Riia Plihtari and Miriam Lee-Rueckert and Petri T. Kovanen},
  journal={Journal of lipid research},
  volume={56 2},
Atherosclerotic lesions are often hypoxic and exhibit elevated lactate concentrations and local acidification of the extracellular fluids. The acidification may be a consequence of the abundant accumulation of lipid-scavenging macrophages in the lesions. Activated macrophages have a very high energy demand and they preferentially use glycolysis for ATP synthesis even under normoxic conditions, resulting in enhanced local generation and secretion of lactate and protons. In this review, we… CONTINUE READING
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