Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC.

@article{Jensen1993AcidificationAD,
  title={Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC.},
  author={Peter Egede Jensen},
  journal={Journal of immunology},
  year={1993},
  volume={150 8 Pt 1},
  pages={3347-56}
}
The hypothesis that reduction of disulfide bonds and exposure to low pH may be sufficient to allow intact proteins to bind class II MHC was addressed in this study. Functional assays were used to determine minimal conditions sufficient to bypass the requirement for Ag processing. Fixed APC, pulsed with HEL at pH 5 in the presence of a reducing agent, were observed to stimulate I-Ed-restricted T cell hybridomas. Activity required both low pH and reducing agent. Fixed APC also stimulated… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…