Acidic urine pH is associated with elevated levels of free urinary benzidine and N-acetylbenzidine and urothelial cell DNA adducts in exposed workers.

@article{Rothman1997AcidicUP,
  title={Acidic urine pH is associated with elevated levels of free urinary benzidine and N-acetylbenzidine and urothelial cell DNA adducts in exposed workers.},
  author={Nathaniel Rothman and Glenn Talaska and Richard B Hayes and Vijai K Bhatnagar and Douglas A. Bell and Vijaya M. Lakshmi and Suresh Kumar Kashyap and Mustafa Dosemeci and Rekha Kashyap and Fong Fu Hsu and Marcus J{\"a}ger and Ari P Hirvonen and Dinesh J Parikh and Bernard B. Davis and Terry V. Zenser},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={1997},
  volume={6 12},
  pages={1039-42}
}
We evaluated the influence of urine pH on the proportion of urinary benzidine (BZ) and N-acetylbenzidine present in the free, unconjugated state and on exfoliated urothelial cell DNA adduct levels in 32 workers exposed to BZ in India. Postworkshift urine pH was inversely correlated with the proportions of BZ (r = -0.78; P < 0.0001) and N-acetylbenzidine (r = -0.67; P < 0.0001) present as free compounds. Furthermore, the average of each subject's pre- and postworkshift urine pH was negatively… CONTINUE READING