Acidic tumor microenvironment and pH-sensing G protein-coupled receptors

  title={Acidic tumor microenvironment and pH-sensing G protein-coupled receptors},
  author={Calvin R. Justus and Lixue Dong and Li V Yang},
  booktitle={Front. Physiol.},
The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection force for cancer cell somatic evolution. Acidic pH has pleiotropic effects on the proliferation, migration, invasion, metastasis, and therapeutic response of cancer cells and the function of immune cells, vascular cells, and other stromal cells. However, the molecular… CONTINUE READING
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