Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion.

@article{Han2006AcidicPF,
  title={Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion.},
  author={S. -H. Han and Chang Woo Lee and Jong Soon Kang and Yeo Dae Yoon and Ki Hoon Lee and Kiho Lee and Song-Kyu Park and Hwan Mook Kim},
  journal={International immunopharmacology},
  year={2006},
  volume={6 4},
  pages={697-702}
}
The acidic polysaccharide (PL) from Phellinus linteus is an immunostimulator that has therapeutic activity against cancers. Here, we show that PL markedly inhibits melanoma cell metastasis in mice, and report that PL directly inhibits cancer cell adhesion to and invasion through the extracellular matrix, but that it has no direct effect on cancer cell growth. In addition, we found that PL increased macrophage NO production. These results suggest that PL has two antimetastatic functions, i.e… CONTINUE READING

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