Acidic pH promotes the formation of toxic fibrils from beta-amyloid peptide.

@article{Su2001AcidicPP,
  title={Acidic pH promotes the formation of toxic fibrils from beta-amyloid peptide.},
  author={Yeu Su and Peter Ta Chen Chang},
  journal={Brain research},
  year={2001},
  volume={893 1-2},
  pages={287-91}
}
Beta-amyloid (Abeta) peptides, the major component of senile plaques in brains of patients with Alzheimer's disease (AD), were found in the low pH organelles (i.e. endosome/lysosome) of cultured neuronal cells. Since acidic pH values have been shown to promote the self-assembly of Abetas, which seems to be a prerequisite for their neuropathogenicity, elucidating the aggregation behavior of Abetas in acidic environments and their subsequent effects on neuronal cells may be crucial for… CONTINUE READING
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