Acidic pH enables caeruloplasmin to catalyse the modification of low-density lipoprotein.

@article{Lamb1994AcidicPE,
  title={Acidic pH enables caeruloplasmin to catalyse the modification of low-density lipoprotein.},
  author={David J. Lamb and David S. Leake},
  journal={FEBS letters},
  year={1994},
  volume={338 2},
  pages={122-6}
}
LDL oxidation within the arterial wall may contribute to the disease of atherosclerosis. There is some evidence that elevated plasma levels of copper are associated with an increased risk of coronary artery disease. We have investigated the conditions under which caeruloplasmin (the plasma copper carrier protein) can catalyse the macrophage-mediated modification of LDL. Low concentrations of CuSO4 (< 1 microM) could catalyse the macrophage-mediated modification of LDL. Native caeruloplasmin was… CONTINUE READING

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