Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism.

@article{Hartl2009AcidicMC,
  title={Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism.},
  author={Dominik Hartl and Chuan Hua He and Babara Koller and Carla Graziele Azevedo da Silva and Yasushi Kobayashi and Chun Geun Lee and Richard A Flavell and Jack A Elias},
  journal={Journal of immunology},
  year={2009},
  volume={182 8},
  pages={5098-106}
}
Acidic mammalian chitinase (AMCase) is produced during and plays an important role in the pathogenesis of Th2-mediated diseases and antiparasite responses. However, the effector responses of AMCase in these settings have not been adequately defined and the relationship(s) between its chitinolytic and other biologic properties have not been investigated. In these studies, we demonstrate that AMCase protects airway epithelial cells from Fas ligand- and growth factor withdrawal-induced apoptosis… CONTINUE READING

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