Acidic deoxycholic acid and chenodeoxycholic acid induce interleukin-8 production through p38 mitogen-activated protein kinase and protein kinase A in a squamous epithelial model.

@article{Shan2013AcidicDA,
  title={Acidic deoxycholic acid and chenodeoxycholic acid induce interleukin-8 production through p38 mitogen-activated protein kinase and protein kinase A in a squamous epithelial model.},
  author={Jing Shan and Tadayuki Oshima and Hirokazu Fukui and Jiro Watari and Hiroto Miwa},
  journal={Journal of gastroenterology and hepatology},
  year={2013},
  volume={28 5},
  pages={823-8}
}
BACKGROUND AND AIM Immune-mediated mucosal inflammation characterized by the production of interleukin (IL)-8 is associated with the development of gastroesophageal reflux disease. The effects of bile acids, which are major components of reflux fluid, on the production of IL-8 and related mechanisms remain unclear. This study aimed to address these questions using an esophageal stratified squamous epithelial model. METHODS Normal human esophageal epithelial cells were seeded on the Transwell… CONTINUE READING

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